It is caused by haploinsufficiency of the Lis1 gene product, which seems to be required for proper functioning of cytoplasmic dynein during neuronal proliferation, migration and morphogenesis.
Scientists have uncovered the intricate circuit cues behind neuronal cell maturation and migration, which is required for proper cognitive function. The journey of a thousand miles begins with a ...
David Solecki, PhD, St. Jude Department of Developmental Neurobiology identified a “coincidence detection circuit” responsible for the migration of mature neuronal cells from the germinal zone and ...