we exposed mouse and human intestinal organoids (self-organized 3D tissues derived from intestine-resident stem cells) to RANKL. We observed a reorganization and marked expansion of the intestinal ...

Researchers from the Organoid group at the Hubrecht Institute have developed a new way to grow organoids. Organoids are tiny ...

Our approach to organoid culture and differentiation involves the use of synthetic matrices to direct morphogenesis through tunable biochemical and mechanical signals. We spatiotemporally pattern ...

Advances in three-dimensional organoid technology have revolutionized the stem cell field. Intestinal stem cells can be expanded and functionally differentiated to form “mini-organs” or organoids that ...

Huch’s pancreatic organoids are now a promising avenue for disease modeling and generating precision medicines to treat ...

During the development of the olfactory epithelium (OE), olfactory sensory neurons (OSNs) express only one member of the odorant receptor (OR) gene family, and O ...

Although tissues generated from intestinal organoids resemble the mucosa, functional smooth muscle layers and the neural plexus are absent. An example that highlights the clinical importance of ...