The study, published in Diabetologia, a top journal in the field of diabetes, demonstrates that HPH-15 outperforms metformin by activating AMP-activated protein kinase (AMPK)—a critical protein ...

While metformin has long been a standard therapy ... The compound’s ability to activate AMPK and reduce glucose levels without excessive lactic acid production could represent a safer ...

Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...

Therefore, AMPK is a prime mediator of the health benefits associated with CR. Metformin and resveratrol are two CR mimetics (CRMs) that induce AMPK activation and contribute to an extended ...