▎药明康德内容团队编辑  剧烈锻炼后，往往第二天我们就会感觉到肌肉酸痛，这种感觉与运动导致的乳酸堆积有一定关系。其实，长时间运动后，流入大脑的乳酸也会增多。而科学家最近发现，这些乳酸对脑细胞的新生很重要。日前，中国科学院遗传与发育生物学研究所郭伟翔研 ...

生命科学Life science2025年1月6日，中国科学院遗传与发育生物学研究所郭伟翔研究组在Cell Press细胞出版社期刊Developmental Cell上发表了题为“Lactate shuttling links histone ...

Furthermore, Mdm2 not only functions as an E3 ligase in the degradation of p53, but is also involved in exporting p53 out of the nucleus before its degradation.

Kymera Therapeutics Inc. has published the characterization of KT-253, a novel compound designed to degrade the murine double minute 2 (MDM2) protein, offering a promising approach for cancers ...

Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...

The orally-available MDM2-p53 agonist is designed to restore the function of p53, the most frequently mutated gene in cancer, which has so far resisted drug development efforts. The p53 gene ...

It focuses on its lead product candidate, ALRN-6924, which is a cell-permeating peptide that disrupts the interaction of p53 suppressors MDM2 and MDMX with tumor suppressor p53 to reactivate tumor ...

INR:0411. hardik pandya age Hebo Pharmaceuticals passed the hearing of the Hong Kong Stock Exchange and 4 innovative drug candidates have entered the clinical s ...