▎药明康德内容团队编辑  剧烈锻炼后，往往第二天我们就会感觉到肌肉酸痛，这种感觉与运动导致的乳酸堆积有一定关系。其实，长时间运动后，流入大脑的乳酸也会增多。而科学家最近发现，这些乳酸对脑细胞的新生很重要。日前，中国科学院遗传与发育生物学研究所郭伟翔研 ...

生命科学Life science2025年1月6日，中国科学院遗传与发育生物学研究所郭伟翔研究组在Cell Press细胞出版社期刊Developmental Cell上发表了题为“Lactate shuttling links histone ...

However, loss of p53 tumour-suppressor activity can also occur through amplification of MDM2. As MDM2 is a negative regulator of p53, this promotes p53 degradation and inhibits p53 tumour ...

Kymera Therapeutics Inc. has published the characterization of KT-253, a novel compound designed to degrade the murine double minute 2 (MDM2) protein, offering a promising approach for cancers ...

Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...

The orally-available MDM2-p53 agonist is designed to restore the function of p53, the most frequently mutated gene in cancer, which has so far resisted drug development efforts. The p53 gene ...

INR:0411. hardik pandya age Hebo Pharmaceuticals passed the hearing of the Hong Kong Stock Exchange and 4 innovative drug candidates have entered the clinical s ...

It focuses on its lead product candidate, ALRN-6924, which is a cell-permeating peptide that disrupts the interaction of p53 suppressors MDM2 and MDMX with tumor suppressor p53 to reactivate tumor ...