Drugs that target the proinflammatory mediator IL-1, for instance, can counteract disease in certain types of inflammatory conditions. But such drugs do not work well for other conditions ...
Mediators of anaphylactic reactions:- Aside from mast cell tryptase, which other chemical inflammatory mediators offer potential as indicators of anaphylaxis? Why this is important:- Although mast ...
The phospholipid PAF is a potent inflammatory mediator that activates all inflammatory cells, and many of the cardiovascular and renal systems. We discovered a new class of phospholipids derived from ...
Most clinical trials targeting blockade of specific inflammatory mediators have not been successful, but activated protein C (APC) has recently been approved for treatment of severe cases of sepsis.
with prolonged inflammation leading to stem cell exhaustion (Cell Reports, 2016). We recently demonstrated that the cell surface expressed protein BST2 is a critical mediator of IFNγ-dependent HSC ...