Epithelial NF-κB preserves the integrity ... hyperactivation of this transcription factor results in chronic inflammatory bowel disease.

The discovery by a MedUni Vienna research team that the trigger for IBD could be found on the surface of intestinal epithelial cells provides a new potential starting point for the development of ...

Active intestinal inflammation in IBD patients is characterized by transepithelial migration of neutrophils into the mucosal epithelium, which has been shown to be associated with differential ...

By trawling through databases of RNA sequences based on models of intestinal damage, a team of researchers led by scientists ...

The epithelial monolayer is covered with a ... The microbiota composition is altered in colorectal cancer (CRC) and inflammatory bowel disease. Intestinal bacteria affect intestinal stem cell ...

Furthermore, there were detrimental consequences for IBD patient-derived intestinal epithelial cells bearing loss-of-function mutations within virus sensor MDA5 when exposed to viromes. Our results ...

Our company wanted to go into IBD as it is a very ... In terms of the mechanism, intestinal PHD1/2-HIF-1α signaling is critical for maintaining epithelial barrier integrity by regulating ...

Inflammatory bowel diseases such as Crohn’s Disease and ulcerative colitis are chronic conditions that can cause severe pain ... These changes can result in thinning of the mucus layer and bacteria ...

Savidge's lab is focused on emerging research concepts, including the interaction of microbes with epithelium, immune cells and nervous system in the induction ... are important regulators of mucosal ...

"Innovative therapeutics for autoimmune diseases of the intestinal mucosa have largely been dominated by injectable drugs. Our small molecule, OR-812, has the potential to offer IBD patients a ...