As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Kupffer cells (KCs) also contribute to this inflammation by activating hepatic stellate cells (HSCs). A reduced expression of complement receptor of the immunoglobulin superfamily (CRIg ...

This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells become activated during hepatitis, often resulting in liver cancer or cirrhosis, both of which can be fatal.

The HepaStem cells have immunomodulatory properties, similar to other MSCs, and act on the hepatic stellate cells that drive hepatic fibrosis. These immunomodulatory, antifibrotic, and liver ...

Activation of Kupffer cells (liver-resident macrophages) and hepatic stellate cells (HSCs) contributes to inflammation and fibrosis, which are key features of ALD progression. The review ...

This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells become activated during hepatitis, often resulting in liver cancer or cirrhosis, both of which can be fatal.

The liver is largely comprised of hepatocytes, but Kupffer cells, endothelial cells and hepatic stellate cells are also present. A perfusion-independent method to isolate ultrapure liver ...

肝脏是人体再生能力最强的实体器官。然而，持续的慢性肝损伤会显著抑制肝脏再生能力，进而导致肝纤维化的发生。肝星状细胞（Hepatic stellate ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...