Methylation is one of the more prevalent chemical modifications that histones undergo. Researchers have previously found that the methylation of one particular location, lysine-4, on histone H3 ...

Methylation of cytosines in CpG dinucleotides ... Briefly, the four nucleotides (A, T, G and C) are added sequentially by a Pyrosequencing instrument to DNA templates. For every successful ...

Data sources 26 skeletal muscle and 86 imprinted genes were subjected to g:Profiler ontology analysis. Meta-analysis assessed exercise-associated DNA methylation change. Data extraction g:Profiler ...

G-quadruplexes are also being explored as potential targets ... Investigating how modifications to guanine, such as oxidation or methylation, affect gene expression and cellular processes is another ...

The findings may also help explain why reducing methylation, which is what the new IDH inhibitor vorasidenib does, only works early in the disease. Later in the disease, other genetic drivers that ...