Here we discuss diacylglycerol-mediated insulin resistance as an alternative and unifying hypothesis to explain the most common forms of insulin resistance associated with obesity and type 2 ...

In mouse thymocytes, positive regulation of inducible T cell kinase (ITK ... of sufficient amounts of the second messenger lipid diacylglycerol to trigger positive selection and the generation ...

This is a useful study that adds new data to how different DAG pools influence cellular signaling, and dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from ...