Solving a 30-year mystery Boulton became interested in dynamic single-molecule analysis when studying RAD51 — an enzyme regulated by BRCA2 to repair double-strand DNA breaks. Multiple RAD51 ...

What’s special about the enzyme you investigated, 8-oxoguanine DNA glycosylase-1 (OGG1)? OGG1 is a DNA repair enzyme that removes damaged DNA nucleobases. DNA is not an inert molecule ...

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby ...

PARP is an enzyme that binds to and helps repair damaged DNA. PARP inhibitors block the enzyme from performing repair, ...

RNA repair enzymes capable of sealing 2’,3’-cyclic-PO 4 /5’-OH breaks or 3’-OH/5’-PO 4 breaks are present in diverse taxa in all phylogenetic domains of life. ATP-dependent RNA ligases join 3’-OH and ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their ... functions like cell ...

DNA polymerase enzymes facilitate this process, ensuring accurate copying of the genetic information ... To maintain the integrity of the genetic information, cells have evolved various DNA repair ...

Mutational signatures etched into the cells' genome by an anti-cancer drug called temozolomide (TMZ) uncover an Achilles' heel for TMZ chemotherapy resistance, according to new research.

The team compared a mouse model with reduced levels of ERCC1-XPF, a DNA repair enzyme, with both young, healthy mice and naturally aging mice. By just 3 months of age, the model showed signs of ...

Ilya Finkelstein’s research focuses on improving gene editing, understanding DNA repair and finding disease treatments.