Comparison of several high resolution complexes of DNA polymerases bound with relevant substrates indicates that the two major families of polymerases function by very similar mechanisms.
DNA polymerase (DNAP) is a type of enzyme that is responsible for forming new copies of DNA, in the form of nucleic acid molecules. Nucleic acids are polymers, which are large molecules made up of ...
The double helix unwinds, and each strand serves as a template for the synthesis of a new complementary strand. DNA polymerase enzymes facilitate this process, ensuring accurate copying of the genetic ...
An analogous process occurs during chromosomal DNA replication, whereby the 5’-RNA segments that prime discontinuous synthesis of Okazaki fragments are excised, and the intervening gaps are filled in ...
DNA polymerase enzymes use the existing DNA strand as a template and add the complementary ... or shifting the reading frame, potentially leading to altered gene function or genetic disorders. Thymine ...