Cells have a warning system to detect DNA in the cytosol, which involves activation of STING, which in turn coordinates ...

When STING is triggered, TANK-binding kinase (TBK1) activates and leads to interferon production. However, Tan and his team ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

The presence of DNA in the cytosol is indicative of cellular damage or infection and leads to activation of genes associated with the immune response. One way cytosolic DNA is sensed is via the ...