The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

此外，研究还鉴定出多个与DNA损伤修复相关的重要翻译后修饰位点，例如p53的K120是调控其 ... functional elements of the DNA damage response through base editor ...

Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53. Figure 2: Destructive pathways: SUMOylation of Mdm2 ...

In the case of DNA damage, the p53 protein has the task of blocking the proliferation of the affected cell, thus providing extra time for repairs. Should this repair fail, the cell self-destructs ...

“In each of our cells,” Alessandro Cellerino, an author on the study, said in the press release, “the DNA sustains damage ...