A new study has uncovered a direct link between somatic mutations and epigenetic modifications, challenging established views ...

The marks influence which genes are expressed or what levels they’re expressed at. Most methylation occurs at specific locations in the DNA, typically on a cytosine (C) that sits next to a guanine (G) ...

Figure 1 | Proposed mechanism of DNA methylation and demethylation. A) Within the genome, the majority of CpG pairs are methylated by addition of –CH 3 to cytosine. B) DNA methylation involves ...

Histone modification can also attract DNA methyltransferases to initiate cytosine methylation, which in turn can reinforce histone modification patterns conducive to silencing. Experiments in ...

Cytosine can undergo chemical modifications that play crucial roles in gene regulation and epigenetics. The most common modification is the addition of a methyl group to carbon 5, forming ...

Discover how genes define individuality, how new genes are created, and how evolution shapes our genome in 2024 research ...

Information is encoded through selective methylation on cytosine bases in DNA. - Pre-synthesized DNA fragments, called DNA bricks, are assembled on a reusable DNA strand. Each DNA brick binds to a ...

5-Methylcytosine is a modified nucleobase formed by the enzymatic addition of a methyl group to the 5th carbon of cytosine. This modification is involved in epigenetic regulation, gene silencing, and ...