8月19日，中国科学院成都生物研究所生物资源利用中心王飞研究团队联合四川大学化学学院冯小明院士和董顺喜教授团队在药物化学国际顶级期刊Journal of Medicinal Chemistry上发表题为“Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

TUNEL staining also showed reduced apoptosis in rats treated with genistein. Genistein also inhibited Nlrp3/caspase-1 signalling, unveiling the effects of genistein in altering molecular pathways in ...

For example, researchers will measure cell death to determine a drug’s anticancer effectiveness. Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark ...

Semiconductors have a valence band that is filled with electrons and an empty conduction band separated by a band gap (also called energy gap). For an electron to be excited into the conduction ...

Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis involves abnormal accumulation of neutrophils and T-cell related abnormalities. Pyroptosis is a type of regulated ...

Epub 2024 May 1. PMID: 38697117; PMCID: PMC11096006 ... Integration of innate immune signalling by caspase-8 cleavage of N4BP1. Nature. 2020 Nov;587(7833):275-280. doi: 10.1038/s41586-020-2796-5. Epub ...

Cleavage of Caspase 3, PARP1 and HSP90, as well as increased Annexin V positivity ... The five-drug combination decreased the levels of BCL-2, BCL-xL and MCL-1, suggesting its potential clinical ...

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