NG-348 encodes two immunomodulatory membrane-integrated T cell proteins: a membrane-anchored, full-length human CD80 and a membrane-anchored antibody fragment specific for the T cell receptor CD3 ...

The antibody is intended for individuals who have ... inhibiting its interaction with PD-1 and cluster of differentiation 80 (CD80) proteins. The review was part of an initiative by the FDA's ...

Functional inactivation of IL-2 by neutralizing antibodies prevented the induction ... but the absence of CD80 or CD86 co-stimulation, may be important for inducing T cell responses during viral ...