Nature1 年
Transforming the CAR-T landscape: platforms pioneer state-of-the-art immunotherapeutics
When expressed in CAR-Ts, this chimeric receptor competes with inhibitory endogenous CTLA4, while simultaneously delivering a stimulatory CD28 signal to the CAR-Ts (converting a negative signal to ...
A battle of rafts: How molecular dynamics in CAR T cells explain their cancer-killing behavior
A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor ...
technologynetworks7 天
Study Reveals How Two Common CAR T Cells Kill Cancer
A study explores the molecular dynamics of CD28.ζ-CAR and 4-1BB.ζ-CAR T cells at the immune synapse, where CAR T cells bind ...
technologynetworks9 个月
GMP Human 4-1BB Ligand Protein for T, NK, and DC Cell Culture
During this process, the CD28-mediated co-stimulatory signal plays a central role. Multiple studies have now demonstrated that 4-1BBL can independently provide co-stimulatory signals to induce T cell ...
来自MSN9 天
Research explores molecular dynamics of CAR T cells in cancer treatment
In this study, researchers aimed to understand how CAR T cells with different signaling domains work at the molecular and cellular levels to lay the foundation for designing CAR molecules that ...