Blocking NMDA receptor activity abolished LTP-mediated inhibition of LTD, showing that transient activation of NMDA receptors mediates this effect. To investigate the downstream signalling ...

The action does not block the current but slows receptors down, so the current is only slightly inhibited. According to Popescu, finding the exact site where ketamine attaches to the NMDA receptor ...

Its precise actions in the brain aren’t well understood, but many of its effects may result from blocking NMDA receptors, stopping them from being activated by the brain chemical glutamate.

so the important issue could be achieving a partial block of the NMDA receptors, rather than which receptor subtype is targeted. Certain forms of synaptic plasticity can be influenced by NMDA ...

The team analyzed samples from human postmortem brains, including healthy individuals and patients at various stages of neurodegeneration. The results show a distinct distribution of NMDA ...