The adenine base editor corrected the most common mutation associated with Stargardt disease in the ABCA4 gene with no ...

Mutations can occur when adenine is altered or mismatched with other bases. For example, the deamination of adenine can lead to the formation of hypoxanthine, which can pair with cytosine instead of ...

developed a highly optimized adenine base editor delivered by adeno-associated viral vectors (AAVs) to correct the most common mutation associated with Stargardt disease. "Our approach achieved ...

How can just four nitrogenous bases--adenine, cytosine, guanine, and uracil--possibly code for all 20 amino acids? Thus, early researchers quickly determined that the smallest combination of As ...

In the double helix structure of DNA, thymine forms a base pair with adenine through two hydrogen bonds. This specific pairing is known as complementary base pairing and is essential for the stability ...