An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

The prize was for the determination of the detailed mechanism by which ATP shuttles energy. The enzyme which makes ATP is called ATP synthase, or ATPase, and sits on the mitochondria in animal cells ...

The prize was for the determination of the detailed mechanism by which ATP shuttles energy. The enzyme which makes ATP is called ATP synthase, or ATPase, and sits on the mitochondria in animal cells ...

Nonetheless, all remodelers contain a subunit with a conserved ATPase domain. In addition to the conserved ATPase, each remodeler complex also possesses unique proteins that specialize it for its ...

This enzyme is the hydrogen-potassium ATPase pump (H+/K+ ATPase), or, more simply, the proton pump. It normally functions to release H+ ions, forming hydrochloric acid that gets released into your ...

Here the authors identify Mcm4 as the key ATPase in this process and show that helicase ring closure around DNA promotes Mcm4 ATPase dependent Cdt1 release, while defective ring closure leads to ...