近期，糖岭生物公布关于抗体偶联药物的一项创新成果获得了国家知识产权局的专利授权，专利名为《二糖连接子、二糖-小分子药物偶联物以及糖链定点抗体-药物偶联物，其制备方法及用途》。该专利涵盖了一种创新的ADC定点偶联方法，该方法利用抗体Fc结构域N297位 ...

Novel Dual-Payload Antibody-Drug Conjugate, at EORTC-NCI-AACR 2024 GlobeNewswire October 23, 2024 SAN FRANCISCO and SINGAPORE, Oct. 23, 2024 (GLOBE NEWSWIRE) -- Hummingbird Bioscience, a precision ...

Biotransformation processes can lead to the creation of different in vivo forms of ADCs, which may impact the drug-to-antibody ratio (DAR) or alter the payload and linker. Typically, PK assays ...

Typically, the therapeutic molecule, known as the ADC payload, is a highly potent small-molecule cytotoxin that delivers the therapeutic effect. A linker connects the payload to the mAb ...

立即申请 Payload是抗体偶联药物（ADC）的关键组成部分，其活性和理化性质直接影响ADC药物的抗肿瘤功效。抗Payload抗体是临床前及临床阶段一种关键的分析工具，可评估ADC药物的稳定性、安全性和有效性。义翘神州已成功开发一系列高质量抗Payload单抗，用于检测 ...

The report delves into various aspects of the ADC market, offering detailed market segmentation based on payload type, linker technology, antibody used, and therapeutic indications. In addition ...

High DAR Dual-Payload ADC Sutro unveils unique cell-free capabilities Proprietary cell-free platform enables the design of ...

DelveInsight's 'Antibody-drug Conjugates in Oncology Competitive Landscape – 2024' report provides comprehensive global ...

including STRO-004 (tissue factor-targeting ADC), dual-payload ADCs (ADC2) and immunostimulatory ADCs (iADC). “The precise design enabled by Sutro’s cell-free platform has allowed us to ...

preclinical data has demonstrated greater anti-tumor activity and lower toxicity compared to a benchmark tissue factor ADC Preclinical models highlight potent anti-tumor activity of Sutro dual-payload ...