Novel Dual-Payload Antibody-Drug Conjugate, at EORTC-NCI-AACR 2024 GlobeNewswire October 23, 2024 SAN FRANCISCO and SINGAPORE, Oct. 23, 2024 (GLOBE NEWSWIRE) -- Hummingbird Bioscience, a precision ...
Biotransformation processes can lead to the creation of different in vivo forms of ADCs, which may impact the drug-to-antibody ratio (DAR) or alter the payload and linker. Typically, PK assays ...
Typically, the therapeutic molecule, known as the ADC payload, is a highly potent small-molecule cytotoxin that delivers the therapeutic effect. A linker connects the payload to the mAb ...
The report delves into various aspects of the ADC market, offering detailed market segmentation based on payload type, linker technology, antibody used, and therapeutic indications. In addition ...
including STRO-004 (tissue factor-targeting ADC), dual-payload ADCs (ADC2) and immunostimulatory ADCs (iADC). “The precise design enabled by Sutro’s cell-free platform has allowed us to ...
preclinical data has demonstrated greater anti-tumor activity and lower toxicity compared to a benchmark tissue factor ADC Preclinical models highlight potent anti-tumor activity of Sutro dual-payload ...